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ba0005ht2 | (1) | ECTS2016

Mice lacking estrogen receptor α in hypothalamic POMC neurons display enhanced estrogenic response on cortical bone mass

Farman Helen , Windahl Sara , Clegg Deborah , Xie Shang Kui , Westberg Lars , Isaksson Hanna , Egecioglu Emil , Schele Erik , Johnsson John Olov , Tuukkanen Juha , Hahner Lisa , Zehr Jordan , Lagerquist Marie , Ohlsson Claes

Estrogens are important regulators of bone mass and exert their physiological effects on bone mainly via estrogen receptor α (ERα). Central ERα has been reported to exert an inhibitory role on bone mass. ERα is widely distributed in the brain with a high expression in the arcuate nucleus (ARC) and the ventral medial nucleus (VMN) in the hypothalamus. Here, we tested the hypothesis that ERα in hypothalamic pro-opiomelanocortin (POMC) neurons, located in...

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ba0005op11 | Pre-Clinical | ECTS2016

Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment

Gustafsson Karin , Farman Helen , Lionikaite Vikte , Wu Jianyao , Henning Petra , Andersson Annica , Islander Ulrika , Bernardi Angelina , Windahl Sara , Skrtic Sofia , Sjogren Klara , Koskela Antti , Tuukkanen Juha , Krust Andree , Chambon Pierre , Ohlsson Claes , Lagerquist Marie

see P490....

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ba0005p490 | Steroid hormones and receptors | ECTS2016

Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment

Gustafsson Karin , Farman Helen , Lionikaite Vikte , Wu Jianyao , Henning Petra , Andersson Annica , Islander Ulrika , Bernardi Angelina , Windahl Sara , Skrtic Sofia , Sjogren Klara , Koskela Antti , Tuukkanen Juha , Krust Andree , Chambon Pierre , Ohlsson Claes , Lagerquist Marie

It is well established that estrogen, mainly via estrogen receptor alpha (ERα), has positive effects on bone, but estrogen is not considered as a treatment option against osteoporosis due to negative side-effects in other tissues. ERα is widely subjected to posttranslational modifications (PTMs), which can affect cellular responses to estrogen in a tissue specific manner by influencing the function of ERα and its interactions with other proteins. The in vivo...

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Bone Abstracts

Mice lacking estrogen receptor α in hypothalamic POMC neurons display enhanced estrogenic response on cortical bone mass

Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment

Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment

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